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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SETD1B
All Species:
27.58
Human Site:
Y1710
Identified Species:
46.67
UniProt:
Q9UPS6
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UPS6
NP_055863.1
1923
208732
Y1710
C
A
R
S
E
G
F
Y
T
I
D
K
K
D
K
Chimpanzee
Pan troglodytes
XP_523492
1707
185692
Y1499
G
S
A
R
S
E
G
Y
Y
P
I
S
K
K
E
Rhesus Macaque
Macaca mulatta
XP_001092031
624
66545
R426
A
T
A
T
F
G
A
R
D
S
G
E
F
R
R
Dog
Lupus familis
XP_543382
1925
209302
Y1712
C
A
R
S
E
G
F
Y
T
I
D
K
K
D
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFT2
1985
215333
Y1772
C
A
R
S
E
G
F
Y
T
I
D
K
K
D
K
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510235
695
75024
S497
T
P
T
L
E
S
S
S
S
S
S
E
K
P
H
Chicken
Gallus gallus
Q5F3P8
2008
223067
Y1795
C
A
R
S
E
G
Y
Y
K
I
D
K
K
D
K
Frog
Xenopus laevis
Q66J90
1938
216239
Y1725
C
A
R
S
E
G
Y
Y
K
I
D
K
K
D
K
Zebra Danio
Brachydanio rerio
Q1LY77
1844
204122
Y1633
C
A
R
S
E
G
Y
Y
K
I
D
K
K
D
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001015221
1641
188364
F1442
K
A
N
T
E
D
S
F
N
E
D
R
S
D
E
Honey Bee
Apis mellifera
XP_395451
1406
159180
S1208
D
V
E
D
N
N
G
S
Y
A
S
G
D
G
T
Nematode Worm
Caenorhab. elegans
Q18221
1507
171664
R1309
K
Q
K
R
S
L
V
R
R
P
D
N
E
S
H
Sea Urchin
Strong. purpuratus
XP_791552
1963
220543
Y1749
S
S
R
T
E
G
Y
Y
K
I
S
N
K
E
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q8X0S9
1313
145607
A1115
G
N
T
N
S
V
A
A
A
A
E
A
A
R
L
Conservation
Percent
Protein Identity:
100
37.3
27.9
91.9
N.A.
87.7
N.A.
N.A.
23.1
61.5
55
51
N.A.
24.7
23.9
22.3
21.3
Protein Similarity:
100
50.3
28.8
93.9
N.A.
90.2
N.A.
N.A.
26.7
71.1
66.6
63.6
N.A.
39.4
38.6
35.2
35.2
P-Site Identity:
100
13.3
6.6
100
N.A.
100
N.A.
N.A.
13.3
86.6
86.6
86.6
N.A.
26.6
0
6.6
46.6
P-Site Similarity:
100
26.6
26.6
100
N.A.
100
N.A.
N.A.
26.6
93.3
93.3
93.3
N.A.
53.3
0
20
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
22.2
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
35.4
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
50
15
0
0
0
15
8
8
15
0
8
8
0
0
% A
% Cys:
43
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
8
0
8
0
0
8
0
58
0
8
50
0
% D
% Glu:
0
0
8
0
65
8
0
0
0
8
8
15
8
8
15
% E
% Phe:
0
0
0
0
8
0
22
8
0
0
0
0
8
0
0
% F
% Gly:
15
0
0
0
0
58
15
0
0
0
8
8
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
15
% H
% Ile:
0
0
0
0
0
0
0
0
0
50
8
0
0
0
0
% I
% Lys:
15
0
8
0
0
0
0
0
29
0
0
43
65
8
50
% K
% Leu:
0
0
0
8
0
8
0
0
0
0
0
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
8
8
8
8
0
0
8
0
0
15
0
0
0
% N
% Pro:
0
8
0
0
0
0
0
0
0
15
0
0
0
8
0
% P
% Gln:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
50
15
0
0
0
15
8
0
0
8
0
15
8
% R
% Ser:
8
15
0
43
22
8
15
15
8
15
22
8
8
8
0
% S
% Thr:
8
8
15
22
0
0
0
0
22
0
0
0
0
0
8
% T
% Val:
0
8
0
0
0
8
8
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
29
58
15
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _